The regression of endometriosis with glycosylated flavonoids isolated from Melilotus officinalis (L.) Pall. in an endometriosis rat model
نویسندگان
چکیده
منابع مشابه
ANTIMICROBIAL, ANTIOXIDANT AND ANTIBIOFILM ACTIVITY OF EXTRACTS OF MELILOTUS OFFICINALIS (L.) Pall
In this paper, the antioxidant and antimicrobial activity, the concentrations of total phenols, flavonoids, tannins and proanthocyanidins in the water, acetone, diethyl ether and ethanol extracts of Melilotus officinalis L. were analysed and their effect on the bacterial biofilm formation. The highest concentration of total phenols (36.25 mgGA/g) and tannins (21.25 mgGA/g) were detected in the ...
متن کاملRegression of endometrial explants in a rat model of endometriosis treated with melatonin.
OBJECTIVE To determine the antioxidant, antiinflammatory, and immunomodulatory effects of melatonin on endometrial explants, the distribution of cyclooxygenase-2 (COX-2), the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and levels of malondialdehyde (MDA) in the rat endometriosis model. DESIGN Prospective, placebo-controlled experimental study. SETTING Expe...
متن کاملChemical Constituents and Antioxidant, Anti-Inflammatory and Anti-Tumor Activities of Melilotus officinalis (Linn.) Pall.
Two new p-hydroxybenzoic acid glycosides, namely p-hydroxybenzoic acid-4-O-α-d-manopyranosyl-(1 → 3)-α-l-rhamnopyranoside (compound 1) and 4-O-α-l-rhamnopyran-osyl-(1 → 6)-α-d-manopyranosyl-(1 → 3)-α-l-rhamnopyranoside (compound 2), and seven known compounds, compound 3, 6, 7 (acid components), compound 8, 9 (flavonoids), compound 4 (a coumarin) and compound 5 (an alkaloid), were isolated from ...
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Endometriosis is defined by the presence of ectopic endometrial tissue outside the uterine cavity. Despite being a lead cause of chronic pelvic pain and infertility, its clinical presentation can vary, leading to diagnostic and therapeutic challenges. Extra-pelvic endometriosis is particularly difficult to diagnose owing to its ability to mimic other conditions. Endometrial tissue in a surgical...
متن کاملInnervation of ectopic endometrium in a rat model of endometriosis.
Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain. Mechanisms that maintain the ectopic growths and evoke symptoms are poorly understood. One factor not yet considered is that the ectopic growths develop their own innervation. Here, we tested the hypothesis that the growt...
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ژورنال
عنوان ژورنال: Taiwanese Journal of Obstetrics and Gynecology
سال: 2020
ISSN: 1028-4559
DOI: 10.1016/j.tjog.2020.01.008